China (Mainland)
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- Product Details
Keywords
- 78415-72-2
- Milrinone
- C12H9N3O
Quick Details
- ProName: Milrinone
- CasNo: 78415-72-2
- Molecular Formula: C12H9N3O
- Appearance: white powder
- Application: congestive heart failure unresponsive
- DeliveryTime: in 5-7days
- PackAge: 1KG/aluminum bags or as your requires
- ProductionCapacity: 500 Kilogram/Month
- Purity: 99.8%
- Storage: dry and cool place
- Transportation: delivery: ems/ eub/ usps/ ups/ tnt/ fe...
- LimitNum: 1 Kilogram
Superiority
Details
|
name |
milrinone |
|---|---|
|
type |
small molecule |
|
melting point |
>300 °c |
|
water solubility |
slightly soluble |
|
groups |
approved |
|
description |
a positive inotropic cardiotonic agent with vasodilator properties. it inhibits camp phosphodiesterase activity in myocardium and vascular smooth muscle. milrinone is a derivative of amrinone and has 20-30 times the ionotropic potency of amrinone. [pubchem] |
|
structure |
|
|
pharmacology |
|
|---|---|
|
indication |
indicated for the treatment of congestive heart failure. |
|
pharmacodynamics |
milrinone, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. |
|
mechanism of action |
milrinone inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte camp activity. subsequently, the erythrocyte membrane becomes more resistant to deformity. along with erythrocyte activity, milrinone also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. |
|
absorption |
milrinone is rapidly and almost completely absorbed after oral administration. bioavailability is 92% (in healthy volunteers). |
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